Scientist - DMPK

Scientist – DMPKRedx Pharma is a clinical-stage biotechnology company focused on the discovery and development of novel, small molecule, highly targeted medicines for the treatment of fibrotic diseases and cancer; progressing a pipeline of novel, differentiated drug candidates against biologically validated targets in areas of high unmet medical need, including IPF and fibrostenotic Crohn’s disease. The Company has a strong track record of discovering new drug candidates through its core strengths in medicinal chemistry and translational science, with six Redx discovered molecules now in the clinic. Alongside, its wholly owned assets zelasudil, RXC008, zamaporvint and RXC009, the Company has significant partnership deals with both AstraZeneca and Jazz Pharmaceuticals.The RoleAs a laboratory-based scientist you will be trained to provide support to Redx projects by performing in vitro and in vivo assays that are required to understand the ADME properties of potential drug candidates. This will include assessment of physicochemical properties of compounds as well as DMPK profiling of compounds.ResponsibilitiesIndependently plan, undertake and interpret a wide range of established assays with minimal guidance from the line manager.Establish new analytical/DMPK assays and techniques to meet the requirements of the project(s) and to expand the technical capabilities of the department. Ensure upload templates are established and comply with Company naming conventions, to permit data entry in Corporate database.Drive the review and continuous improvement of assays to ensure maximum capacity is obtained and the highest quality of data is obtained within workflow boundaries.Develop expertise in one-or-more specific analytical/DMPK areas and be recognised as technically skilled in the technology/area.May be a project core team (depending on experience) member or the lead for a particular analytical platform.Actively seek to develop the knowledge of others in your own, and other relevant and initiate scientific discussions within the team.Expand scientific, technical, and drug discovery knowledge by reading scientific literature and attending conferences.RequirementsBSc or MSc in a relevant discipline or equivalent experience.A minimum of 2 years in a relevant previous drug discovery and/or research experience in the DMPK discipline.An understanding of liquid chromatography and mass spectrometry would be beneficial.Experience with permeability assay would be beneficial.An understanding of in vitro ADME assays.A general appreciation of the essential elements of the drug discovery process.CompetenciesResults orientationInnovation & CreativityPlanning & OrganisingCommunication SkillsInterpersonal skills/Team orientationMotivationThoroughnessIn return, we will offer you the opportunity to work at an exciting drug discovery company where you will get exposure to a broad range of activities and develop your drug discovery skills